FDA seeks input on genotyping for pediatric codeine use

The US Food and Drug Administration (FDA) is looking for open counsel on whether youngsters younger than 12 years ought to be allowed to get analgesics containing codeine, on the off chance that they have been cleared from having a hereditary inclination to use the medication at possibly poisonous levels.

Presently, the utilization of items containing codeine is contraindicated in youngsters younger than 12. Codeine, a narcotic demonstrated for alleviation of mellow to direct agony under certain conditions for grown-ups, is incompletely utilized to morphine through the liver's CYP2D6 pathway. In any case, people differ incredibly in their CYP2D6 digestion of codeine. The individuals who are helpless metabolizers may not get adequate absense of pain, though supposed "ultra-quick metabolizers" may encounter narcotic related harmfulness on account of fast rise in serum morphine levels after organization of codeine.

The solicitation for discussion was provoked by a resident request put together by clinical pharmacologists and pharmacogeneticists who asked that the current contraindication to the utilization of codeine-containing items for those matured under 12 years be altered to allow the utilization of these items in those known to be ordinary or moderate CYP2D6 metabolizers.

The candidates noticed that arrangements containing codeine and acetaminophen are delegated Schedule III in the Controlled Substances Act and are in this way ready to be recommended by phone, while other narcotic analgesics reasonable for rewarding torment in this age bunch are Schedule II prescriptions, which can't be endorsed by phone. "The Petitioners recommend that the current contraindication may prompt youngsters under 12 years old with intermittent intense torment to have diminished access to narcotic analgesics, which may bring about more crisis division and pressing consideration visits," composed FDA.

The current contraindication was gone before by a 2013 European Medicines Agency (EMA) assurance that codeine ought not be utilized in those under 12 years, and ought to likewise be maintained a strategic distance from for tonsillectomy or potentially adenoidectomy in youngsters under 18 years old, and in breastfeeding ladies known to be ultra-quick metabolizers. (RELATED: EU Committee Wants Additional Restrictions on Codeine Use in Children, Regulatory Focus, 16 March 2015)

Following a 2015 joint gathering of its Pulmonary and Allergy Drugs and the Drug Safety and Risk Management Advisory Committees, FDA gave a Safety Labeling Change notice letter educating concerning the danger of respiratory wretchedness that could be hazardous in youngsters getting codeine, or bosom taking care of newborn children whose moms got codeine. The notice letter contained the contraindication for utilization of codeine in those under 12 and an admonition for youngsters matured 12 to 18 with chance components for respiratory misery. The enhancements submitted because of the warning letter and refreshed naming were endorsed in August 2017.

In its sales of data and analysis from partners, FDA is likewise requesting discourse on a more extensive area of appropriate themes, remembering elements to consider for endorsing narcotic analgesics for youngsters under 12 years old; which pediatric populaces utilize these drugs; the job, if any a codeine-acetaminophen readiness in this age gathering, and other clinical and recommending questions. The organization likewise is looking for contribution from specialized specialists and prescribers in regards to involvement in CYP2D6 genotyping, subtleties of identification of ultra-fast metabolizers, and clinical utility of the tests. At last, FDA is requesting data in regards to e-endorsing of timetable II narcotics, which may manage the cost of some chance to alleviate the current trouble in getting to intense help with discomfort for youngsters without requiring a facility or crisis division visit.

Herbal Supplement

Andrew Jones Auctions will hold an online only Design for the Home and Garden Auction on July 26th

Downtown Los Angeles, CA, USA, Jul 01, 2020 -- Andrew Jones Auctions’ upcoming Design for the Home and Garden Auction on Sunday, July 26th, will feature over 250 lots of important fine art, design, antiques and accessories from collections across the country and throughout California. This will be an online-only auction, with no live bidding. Phone and absentee bids will be taken.

The sale will be led by property from the collection of Mary and Lou Silver of Indian Wells, California. Highlights include important fine art, sculpture, micro mosaics, antiques, art glass, design and even a Steinway grand piano. Also included is property from a Northern California estate featuring antiques, fine silver and clocks, as well as the Estate of Ruth Harvey of Bel Air.

“It is exciting to have the opportunity to offer such a varied and well-rounded collection as that of Mary and Lou Silver,” said Andrew Jones, the president and CEO of Andrew Jones Auctions. “They both had great eyes for quality and style. The other properties that fill out the auction are quite complementary in caliber.” Auctions’

The Mary and Lou Silver collection encompasses a number of different genres with standout works of art, including a spectacular oil on canvas Still life with flowers and fruit painted by a master of color and composition, Nicolai Fechin, circa 1925 (est. $70,000-$100,000). Another fine work is a gouache on paper abstract composition by Serge Poliakoff (est. 30,000-$50,000).

The collection also offers pieces by Rosa Bonheur, John George Brown, George Fuller, Ernest Lawson, Reginald Marsh, Louis Charles Moeller, Jane Peterson and Helen Maria Turner. Fine art from other sources include Lita Albuquerque, Marc Aldine, Frank Beanland and Leopold Schmutzler, as well as an Edward Hopper etching titled Evening Wind (1921) from a Beverly Hills collector. Also up for bid will be five pieces by Bernard Lorjou, and a monumental floral still life painting by the noted Austrian artist Sebastian Wegmayr from the estate of Ruth Harvey.

Sculpture runs the gamut from French masters like Edgar Degas (Tête, étude pour le portrait de Madame S. [Mathilde Salle], est. $15,000-$20,000), Louis-Ernest’s Barrias’ Nature Revealing Herself Before Science, Émile-Antoine Bourdelle, Claire Jeanne Roberte Colinet, Jean-Léon Gérôme, François-Raoul Larche, Emmanuel Villanis and Marius-Jean-Antonin Mercié’s’ Gloria Victus (est. $10,000-$15,000). Also sold will be three Robert Graham frieze figures and a selection of animalier bronzes after Antoine Louis Bayre, Isadore Bonheur, Hippolyte Joseph Cuvelier, Pierre-Jules Mêne and Leonid Vladimirovich Pozen.

Art glass from the Silver collection includes a Dale Chihuly blown and applied glass Venetian vase, 1996 (est. $8,000-$12,000) and two works by Murano Maestro Lino Tagliapietra – Riverstone, 1998 and Bilbao, 2002, as well as a Marc Lalique Cactus table and other Lalique pieces such as Cygne tête droite and Cygne tête penchée and Masque de Femme. Four larger scale pieces by Dino Rosin, two pieces by Tiffany Studios and an impressive vase by Steven Rolfe Powell are also included.

The Silvers developed a love of the intricacies and subtleties of the art of Italian micro mosaics and their collection includes a spectacular panel of a peasant woman in a country landscape from the workshop of Michelangelo Barberi (1787-1867), Rome (est. $10,000-$15,000), traditional Grand Tour subjects like Roman ruins including a table top centering St. Peter's Square (est. $20,000-$30,000), as well as two pieces formerly in the collection of Gianni Versace, including a lovely floral still life with birds.

English antiques and decorative arts will be led by a selection from a Northern California estate that includes a fine late 18th century George III gilt bronze and jasperware mounted fall front secretary in the manner of Thomas Sheraton, a Regency mahogany cellarette in the manner of Thomas Hope, and two early tall case clocks: a walnut example by Joseph Knibb apprentice Brounker Watts, and a floral marquetry example by Christopher Gould (est. $8,000-$12,000). A graceful early George III mahogany open armchair in the manner of Paul Sanders (est. $2,000-$3,000) is included in the estate of Ruth Harvey.

Also from the Northern California estate is a selection of early British Britannia and sterling silver, including a collection of tumbler cups from London makers, as well as provincial silversmiths, a Charles II porringer, candlesticks, coffee pots, tankards and other table wares. Fine silver from the estate of Ruth Harvey features a pair of substantial Regency tea trays by Paul Storr (est. $5,000-$7,000 each) and a Storr silver tea urn originally owned by Richard Alexander Oswald of Oswald Hall, Ayrshire, Scotland (est. $6,000-$8,000). The silver offerings also include pieces by the Georg Jensen Silversmithy and a striking pair of Viennese silver-gilt figural six-light candelabra (est. $4,000-$6,000).

European decorative arts will showcase clocks and timepieces from the estate of Ruth Harvey, including a Swiss silver mounted mother-of-pearl timepiece (est. $1,000-$1,500), and from a Northern California estate a sculptural Louis XVI figural mantel clock by Jean Baptiste Dutertre (est. $6,000-$8,000) and an allegorical Empire example by Angevin, Paris (est. $4,000-$6,000).

The same source also has a Thomire gilt bronze tazza (est. $2,500-$3,500) and a pair of Louis XVI grey painted fauteuils, circa 1785, by menuisier Nicolas Delaisement (est. $4,000-$6,000). Mary and Lou Silver acquired a stunning Émile Gallé marquetry Japoniste étagère (est. $4,000-$6,000) as well as a gilt bronze mounted mahogany side cabinet by Cueunieres (est. $2,500-$3,500), a gilt bronze mounted mahogany bureau plat (est. $4,000-$6,000) a pair of wonderful Louis XV style gilt bronze chandeliers and broad selections of period lighting and fine carpets.

Additional highlights include two vintage Louis Vuitton travel trunks that belonged to Oscar winning director Orson Welles and his wife, Contessa di Gerfalco, Paola Mori from the estate of Orson Welles (est. $4,000-$6,000 each) and garden appointments as impressive as a pair of French bronze mounted iron jardinieres by the Val d’Osne foundry, vintage Catalina tile bird panels and a number of lots of patio furniture by Walter Lamb for Brown Jordan, as well as marble sculpture and a 19th century Rouge Royal marble fountain.

The auction will start promptly at 11 am Pacific time. Internet bidding will be facilitated by www.AndrewJonesAuctions.com, www.LiveAuctioneers.com and www.Invaluable.com.

The next major auction after this will be titled Important and Fine Jewelry, scheduled for Thursdays, September 10th. Highlights include more of the collection of Mary and Lou Silver, featuring large stone diamonds, pieces by Buccellati, Bulgari, Frascarolo, David Yurman, Tiffany & Co., Van Cleef & Arpels and more, plus clocks and timepieces by Cartier, Le Coultre, Patek Philippe and others.

To learn more about Andrew Jones Auctions and the July 26th and September 10th auctions, visit www.AndrewJonesAuctionas.com.

About Andrew Jones Auctions:
Opened summer 2018 in downtown Los Angeles, Andrew Jones Auctions is a full-service fine art and antiques auction house specializing in the liquidation of estates and collections featuring fine art, antiques and collectibles. The firm understands market trends and has foresight for the 21st century. The staff has a wealth of knowledge with international experience, having worked for many years at major international auction houses in America and Europe, sourcing property from across North America. The sales are fun, diverse and eclectic, featuring items dating from antiquity to the 21st century. Andrew Jones Auctions is always accepting quality consignments for future auctions. To inquire about consigning a single piece, an estate or a collection, you can call them at 213-748-8008; or, you can send an email to This email address is being protected from spambots. You need JavaScript enabled to view it.. To learn more about Andrew Jones Auctions, visit www.AndrewJonesAuctionas.com.

Media Contact:
Aileen Ward
Andrew Jones Auctions
2221 S. Main Street
Los Angeles, CA 90007 (USA)
213-748-8008
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https://www.andrewjonesauctions.com/

ExpertsConsult Connecting Brains Creating Future

Portland, July 1, 2020  - Market research veterans along with the bunch of top industry analysts have teamed up to launch India’s first AI driven knowledge sharing platform and a robust network of top-rated industry experts called – “ExpertsConsult”.

The platform enables global companies to unlock knowledge and industry insights to make smarter and accurate decisions. The platform allows users and knowledge seekers to swiftly connect with industry experts while using ExpertsConsult’s proprietary software and tech algorithms. The robust and vast network comprises of highly experienced industry experts who are registered via 3 step validation protocol which adds a strong layer of authenticity and secure knowledge Sharing.

Being a technology-driven platform it uses advance techniques such as “Artificial Intelligence” to search, find and secure right industry experts for knowledge seekers. The system evaluates more than 30 data points to obtain the most accurate match and eliminates any manual intervention.

ExpertsConsult promises to offer the most innovative and enhanced experience of knowledge sharing such as: 1-on-1 consultations, video and virtual consultations, expert surveys from niche audiences and roundtables covering both, expert webinars, and seminars (virtual). ExpertsConsult will soon enable users to have complete access to their own expert network and will launch other smart search features (later this year). Advanced screening options and smart features will allow users to find and onboard an expert of much faster than other existing players.

To be one of the best, one has to partner with the best and that's exactly what ExpertsConsult offers - “Innovation, future of knowledge sharing and quick, reliable insights to build and transform businesses in a whole new way”.

CEO’s note:-

Knowledge Sharing is the key to be informed and smarter decision making whether it is inter company or within an industry. ExpertsConsult’s platform is designed to bridge the gap between information seeker and an expert in a few easy steps. We are not only focused on making sure we get the right and most knowledgeable industry expert for your consult but also compensate them adequately and quickly for their time. The platform is continuously fuelled by a large team of head-hunters that are constantly looking for top industry experts and opinion leaders to join the network.

Strat O Matic Baseball Simulation Trout Freeman Morton Scherzer Earn June Awards

As Strat-O-Matic’s (www.strat-o-matic.com) simulation of the 2020 baseball season moves past the halfway point and with the All-Star Game less than two weeks away, award winners for June were announced today. Mike Trout of Los Angeles and Freddie Freeman of Atlanta were selected as A.L. and N.L. Players of the Month, respectively, while Charlie Morton of Tampa Bay and Max Scherzer of Washington earned League Pitcher of the Month honors.

 

Tampa Bay (53-34, 9.5 game lead over New York), Cleveland (54-32, nine games ahead of MInnesota), Houston (MLB-best 56-28, six games ahead of Oakland), Washington (51-35, six games better than Atlanta) and Los Angeles (57-29, 8.5 lengths past San Diego) remain atop their respective divisions, while Milwaukee (45-39) moved into the N.L. Central lead with a 14-11 month, percentage points ahead of Chicago (46-40), a game ahead of St. Louis and four better than Cincinnati in the tightest division race to date. Strat-O-Matic updates results and standings daily at www.strat-o-matic.com/2020-season-simulation/.

 

Trout earned the A.L. honors by hitting .327 with 10 home runs and 24 RBI in the month, while posting a 1.136 OPS. Freeman was even better, slashing .378/.461/.724 for a 1.185 OPS in June. Morton won all four of his decisions, pitching to a 1.06 ERA and 0.82 WHIP, fanning 36 across 34 innings, while Scherzer went 5-1 with a 1.89 ERA and 0.95 WHIP, whiffing 53 in 38 innings in the month.

 

The wild card races are very tight in both leagues, with Oakland (51-35) in first place in the A.L., Minnesota (45-41) one game up on Kansas City (44-42) for the second spot, two ahead of New York (43-43), 2.5 up on Los Angeles (42-43) and three ahead of Boston (42-44). In the Senior Circuit, San Diego (48-37) sets the pace, with Central-leading Milwaukee (45-39) and Chicago (46-40) a game better than St. Louis and Atlanta (45-41) and three ahead of Arizona (43-43) for the second slot.

 

Some of the individual league leaders through June 30 include:

  • Shogo Akiyama, Cincinnati, N.L. batting (.349);
  • Nick Madrigal, Chicago, A.L. batting (.342)
  • Trevor Story, Colorado, N.L. home runs (31); runs (75)
  • Jorge Soler, Kansas City, A.L. home runs (31); RBI (91)
  • Keston Hiura, Milwaukee, N.L. RBI (73)
  • Mike Trout, Los Angeles, A.L. runs (77)
  • Clayton Kershaw, Los Angeles, N.L. victories (12); ERA (2.25)
  • Danny Duffy, Kansas City, A.L. victories (10)
  • Gerrit Cole, New York, A.L. victories (10); strikeouts (158)
  • Blake Snell, Tampa Bay, A.L. ERA (2.18)
  • Jacob deGrom, New York, N.L. strikeouts (153)

 

“Just like on the field, the teams have started to separate themselves at the top of each division, but there are still close races and unexpected results in the Strat-O-Matic simulation of the season,” said Hal Richman, Strat-O-Matic founder. “With some of the league’s superstars like Mike Trout, Max Scherzer and Clayon Kershaw among the leaders along with newer faces in Shogo Akiyama, Nick Madrigal and Keston Hiura, the last three months of the season should be as exciting and interesting as the first three have been.”

 

Monthly winners to date:

  • A.L. Player: Jorge Soler (April), Jorge Soler (May), Mike Trout (June)
  • N.L. Player: Trevor Story (April), Daniel Murphy (May), Freddie Freeman (June)
  • A.L. Pitcher: Blake Snell (April), Kenta Maeda (May), Charlie Morton (June)
  • N.L. Pitcher: Stephen Strasburg (April), Luke Weaver (May), Max Scherzer (June)

 

About Strat-O-Matic

Strat-O-Matic was invented by 11-year-old Hal Richman in his bedroom in Great Neck, N.Y. in 1948 as a result of his frustration with the statistical randomness of other baseball board games. He discovered that the statistical predictability of dice would give his game the realism he craved. Over the next decade, he perfected the game at summer camp and then as a student at Bucknell University. After producing All-Star sets in 1961 and ‘62, he parlayed a $5,000 loan from his father (and made a deal that if it didn’t work out he would work for his father’s insurance company) into the original 1962 Strat-O-Matic Baseball season game. Needless to say, Hal never had to take a job with his father.

 

Strat-O-Matic, based in Glen Head, NY and on the Internet at www.strat-o-matic.com, manufactures the top selling sports board games and realism/stats sports digital games. The Company publishes baseball, football, basketball and hockey games to play both on and off your computer and mobile screens. “Strat-O” games are known throughout the sports community for their statistical realism and accuracy. The Company has the world’s greatest sports game stat libraries with top-of-the-line seasons dating back to the early 1900’s. At the start of the 2016 MLB season, Strat-O-Matic introduced Baseball Daily, its first product featuring digital player cards that update every day to reflect real life current player performance as the season progresses.

 

The Company has a loyal celebrity following including a bevy of sports broadcasters such as Bob Costas, Jon Miller and Dan Shulman, former MLB’ers Keith Hernandez, Doug Glanville and Cal Ripken Jr., and sports super fans including Drew Carey, Ben Bernanke, Bryant Gumbel, Spike Lee and Tim Robbins. More information is available at: www.strat-o-matic.com.

Famer And US Sports Camps Partner to Launch Interactive Virtual Youth Camp Programs For Summer 2020

Famer, the sports coaching and mentorship mobile platform, today announced a landmark partnership with US Sports Camps, the largest and most successful youth sports summer program in North America, to bring an interactive and substantive training experience to thousands of young athletes displaced from camp due to COVID-19. US Sports Camps (USSC) is the licensed operator of the NIKE Sports Camps and operates over 1,000 camps in 16 different sports totaling more than 100,000 campers annually.

Our goal this spring was to bring our unique cloud based interactive training technology to the camps market to give kids and parents a meaningful and worthwhile summer experience,” said Famer CEO Rich Abend. “Through launching the concept with the industry leader, US Sports Camps, we know we have found a fun and powerful alternative to keep kids engaged and active, and coaches involved and earning money doing what they love. Our business has grown ten-fold during COVID-19, and we are thrilled to be the go-to solution for virtual training which will continue to be important to athletes and coaches even after we all return to the fields and courts.”

For the past month, USSC has rolled out its new Famer-based digital training platform for virtual camps with select coaches and the early feedback has been very positive from parents and kids.

This has been a difficult time for us at US Sports Camps,” says Justin Hoeveler, EVP of US Sports Camps. “2020 is the first summer in 48 years that we haven’t operated in-person summer sports camps for young athletes. While we decided early in the Spring that there was too much uncertainty around Covid-19 for us to feel comfortable operating our physical camps we did know that the demand for quality coaching and structured training for our campers would remain strong. The partnership with Famer has been tremendous so far. The testing we’ve done this Spring has given us a window to see how young athletes, coaches, and parents can interact, learn and have a positive virtual experience that enhances skill development and athletic performance. We’re excited to continue to digitally connect our coaches and campers through the summer and beyond.”

USSC and its coaches film dynamic skills and drills videos and upload them to the Famer platform. These drill videos are grouped into workouts that are then distributed to campers to view, perform, and record (if they choose). The drill videos that campers record are then shared with USSC coaches to review for accountability and provide feedback through a number of Famer analysis tools like voiceover, telestration, and text. Athletes can choose to sign up for group based or individual digital/virtual camps on Famer for programs lasting between two to five weeks in length. Campers in group-based training are able to interact with each other and their coach in a multi-media group chat that creates camp-like camaraderie.

Famer supports organizations, clubs, and coaches by allowing them to upload their own personal training content or engage with Famer Productions to create custom professionally produced, edited, and curated content that can be hosted, distributed on its platform. Famer was designed to complement in-person practices and training pre-COVID, but with social distancing it has become an essential partner to hundreds of organizations.

Information and registration for the USSC summer virtual youth camp programs can be found at https://www.ussportscamps.com/nike-sports-camps-virtual-training

About Famer

Famer is a mobile coaching platform that enables group, team and personal training programs and interactive feedback between athletes, their coaches and clubs. We support and empower coaches/clubs to organize, enhance and grow their business through technology. Sports include lacrosse, soccer, baseball/softball, basketball, hockey and volleyball, and are being ramped up to include football and tennis soon. Details are at famer.us.

About U.S. Sports Camps

US Sports Camps (USSC), headquartered in San Rafael, California, is America's largest sports camp network. The company has offered summer camps since 1975 with the same mission that defines it today: to shape a lifelong enjoyment of athletics through high-quality sports education and skill enhancement.